Meeting proceedings of the american society of clinical oncology programproceedings of the american society of clinical oncology. American society of clinical oncology educational book. Tumor evolution, heterogeneity, and therapy for our patients with advanced cancer. American society of clinical oncology educational book the asco educational book is an nlmindexed.
Car tcell therapy for solid tumor malignancies is an exciting frontier in cancer immunotherapy. The promise of immunotherapy in the treatment of hepatocellular. Secondline therapies in advanced biliary tract cancers. Novel treatment options in head and neck cancer fulltext. Recognizing and managing on toxicities in cancer immunotherapy. Biliary tract cancers constitute approximately 3% of gastrointestinal malignancies with poor prognosis. The 2015 american society of clinical oncology educational book print issn. What it takes to improve a firstgeneration inhibitor to a second or thirdgeneration small molecule.
Tumor evolution, heterogeneity, and therapy for our. Clinical characteristics, immunohistochemical features, laboratory examinations, and treatment outcome were analyzed among these patients. Volume 147, issue 3, december 2017, pages 493496 fertilitypreserving surgery for advanced stage ovarian germ cell tumors author links open overlay panel dimitrios nasioudis a b melissa k. Current landscape of immunotherapy in genitourinary. Himisha beltran harvard catalyst profiles harvard catalyst. Disease management is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Personalizing therapy for metastatic prostate cancer. Optimal management of early and advanced her2 breast cancer.
As such, women wishing to become pregnant may be advised to delay conception at least for one year following the completion of adjuvant chemotherapy 19 x 19 matei, d. The asco educational book is an nlmindexed collection of articles written by asco annual meeting faculty and. Discussions about clinical trials among patients with newly diagnosed lung and colorectal cancer. Gastric cancer is one of the most common gastrointestinal malignancy with high mortality in east asia. In a 2017 asco census survey completed by 395 practices. He also codirects the parker institute of cancer immunotherapy at ucsf and coleads the cancer immunity program in the helen diller family comprehensive cancer center. Developing and sustaining an effective and resilient oncology. Ed book was launched in 1985 to highlight standards of care and inspire future therapeutic possibilities in oncology. Nam perspectives are expert commentaries and discussion papers by leading voices in health, medicine, biomedical science, and related policy. Its multidisciplinary approach allows readers to keep uptodate with developments in their own as. Physical, psychological, social, and spiritual wellbeing. The ed book is a national library of medicineindexed collection of articles written by asco annual meeting faculty and invited leaders in oncology.
The 2017 asco educational book is published online at edbook. Investigation of pathogenic mechanisms of gastric cancer is crucial to develop novel therapeut. Measuring symptomatic adverse events with the national cancer institutes patientreported outcomes version of the common terminology criteria for adverse events proctcae. From 2000 to 2017, a total of 186 intermediaterisk mrcc patients treated with firstline it n64, 34. She completed a residency in internal medicine and chief residency at the university of massachusetts medical center and an oncologyhematology fellowship at beth israel hospital and harvard medical school. Highdose asian ginseng panax ginseng for cancerrelated fatigue. Maryellen taplin, md danafarber cancer institute boston, ma. Nam and colleagues 43 reported that drugs targeting her2 trastuzumab, dacomitinib, and afatinib showed cell cycle arrest and apoptosis in her2amplified biliary tract cancer cell lines snu2670. Fertilitypreserving surgery for advanced stage ovarian germ.
Prostate cancer screeningwhen to start and how to screen. Epithelial ovarian cancer generally presents at an advanced stage and is the most common cause of gynaecological cancer death. Publications healthcare delivery research national cancer. Molecular and clinical oncology is a monthly medical journal in the field of oncology that covers a wide range of original research, while offering a rapid publication process.
Perspectives on the use of clinical pathways in oncology care. Using the new asco clinical practice guideline for palliative care concurrentwith oncology care using the team approach. Although the combination of gemcitabine and cisplatin is a standard regimen of. Initial therapy includes surgery and adjuvant therapy. Loblaw da, virgo ks, nam r, somerfield mr, benjosef e, mendelson ds, et al. Moving beyond autologous transplantation in multiple myeloma. Journal of clinical oncology original report btkc481smediated resistance to ibrutinib in chronic lymphocytic leukemia jennifer a. Secondary cytoreductive surgery potentially improves the.
Role of interim 18 ffdgpetct for the early prediction. Gridelli c, balducci l, ciardiello f, di maio m, felip e, langer c, et al. Evaluation of the 8th edition of the american joint. Maintenance therapy with tumortreating fields plus. American society of clinical oncology educational book asco. Role of clinical trial participation in cancer research. American society of clinical oncology educational book list of issues. They describe the key elements of an issue, summarize. The association of alternate vegf ligands with resistance to antivegf therapy in metastatic colorectal cancer. Proceedings, annual meeting of the american society of. Initial hormonal management of androgensensitive metastatic, recurrent, or progressive prostate cancer.
Biomarkers may be used in multiple clinical settings in the continuum of cancer diagnosis, treatment, and. View in pubmed effect of firstline chemotherapy combined with cetuximab or bevacizumab on overall survival in patients with kras wildtype advanced or metastatic colorectal cancer. Center for cell engineering, and molecular pharmacology and chemistry program, memorial sloan kettering cancer center, new york, ny. This site uses tracking technologies through the use of permanent cookies and web beaconspixel tags. Nathanael gray, phd danafarber cancer institute boston, ma. Implications for clinical care, research, and policy longterm survivorship care after cancer treatment summary of a 2017 national cancer policy forum workshop. Moving beyond autologous transplantation in multiple. Proceedings of the annual meeting of the american society of clinical oncology related names.
Currently, immunotherapeutic approaches in routine clinical use are limited to antibodies. An overview of existing and emerging biomarkers in oncology. The asco educational book is an nlmindexed collection of articles written by asco annual meeting faculty and invited. Marta penasprados profile, publications, research topics, and coauthors. The promise of immunotherapy in the treatment of hepatocellular carcinoma am soc clin oncol educ book. Populationbased screening has been ineffective, but new approaches for early diagnosis and prevention that leverage molecular genomics are in development. Using the new asco clinical practice guideline for. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Role of immunecheckpoint inhibitors in lung cancer article pdf available in therapeutic advances in respiratory disease 12. Integrating social media in modern oncology practice and. Kamiyamatsuoka c, cachia d, waguespack sg, crane ch, mahajan a, brown pd, nam jy, mccutcheon ie, penasprado m. Developing and sustaining an effective and resilient. Secondline therapies in advanced biliary tract cancers the. Ravi salgias profile, publications, research topics, and coauthors.
Ons is excited to launch a new offering to help connect you with resources and education virtually. Jan 30, 2019 the use of data from the real world to address clinical and policyrelevant questions that cannot be answered using data from clinical trials is garnering increased interest. Despite the clearcut nature of professional society guidelines, uncertainty arises. Clinical relevance or possible limitations of new research studies can also be. Yennurajalingam s, reddy a, tannir nm, chisholm gb, lee rt, lopez g, escalante cp, manzullo ef, frisbeehume s, willliams jl, cohen l, bruera e.
Ovarian neoplasms is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Predicting and preventing anthracyclinerelated cardiotoxicity. Anthony elkhoueiry, md keck school of medicine of usc. Clinical oncology is a part of elsevier s oncology journal network. Immunohistochemical overexpression of bcl2 protein predicts.
Tanaka n, mizuno r, shirotake s, ito k, yasumizu y, masunaga a, et al. Jul 24, 2019 developing a quality of cancer survivorship care framework. Pubmed du l, anderson a, nguyen k, ojeda ss, ortizrivera i, nguyen tn, zhang t, kaoud ts, gray ns, dalby kn, tsai ky. Taplin received her md in 1986 from the university of massachusetts, worcester. Valuebased medicine and integration of tumor biology. In 2017, pembrolizumab received the fdas first tumor siteagnostic approval, instead requiring evidence of high microsatellite instability andor mismatch repair deficiency.
Fertilitypreserving surgery for advanced stage ovarian. Radiotherapy with concurrent temozolomide for the management of extraneural. Treatment of advanced nonsmallcell lung cancer with epidermal growth factor receptor egfr mutation or alk gene rearrangement. Clinical oncology is essential reading for all those with an active interest in the treatment of cancer. Clinical oncology has an international editorial board led by c. Cytoreduction surgical procedures is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings.
Yennurajalingam s, reddy a, tannir nm, chisholm gb, lee rt, lopez g, escalante cp, manzullo ef, frisbeehume s, willliams. In the 8 years since the publication of the 4th edition of the who classification of hematopoietic and lymphoid tumours in 2008, there has been rapid accumulation of knowledge in the molecular genetics, biology, and clinical behavior of many hematologic malignancies. Age ranged from 16 to 78 years old, and 29 patients 35. Updates in the management of ovarian germ cell tumors. Maryellen taplin harvard catalyst profiles harvard. Lieu ch, tran h, jiang zq, mao m, overman mj, lin e, eng c, morris j, ellis l, heymach jv, kopetz s. The 2015 asco educational book is published online at edbook. Immunohistochemical overexpression of bcl2 protein.
Btkc481smediated resistance to ibrutinib in chronic. The widespread adoption and diffusion of social media provides oncology. Therapeutic targets and opportunities in endometrial cancer. Dosedense temozolomide for newly diagnosed glioblastoma. Patientreported outcomes in cancer clinical trials. The same year saw the first approvals for adoptive cellular therapies in aggressive childhood leukemias and adult lymphomas 29. Evolving recommendations on prostate cancer screening. Heerema, weiqiang zhao, joshua coleman, daniel jones, lynne abruzzo, amber gordon, rose mantel, lisa l. The general architecture of a car consists of a singlechain variable fragment scfv derived against a predetermined tumorassociated antigen taa followed by a cd3. Is there currently an established role for the use of predictive or prognostic molecular markers in the management of colorectal cancer. Effect of reclassification of the imdc model in patients with metastatic renal cell carcinoma treated with targeted therapy in the firstline and secondline settings. American society of clinical oncology educational book rg. Update on endocrine therapy and nonimmunotherapy targeted options.